Drug Stereochemistry: Analytical Methods and Pharmacology
Krzysztof Jozwiak,W. J. Lough,Irving W. Wainer
ISBN: 9781420092387
Vydavatelství: Taylor & Francis
Rok vydání: 2012
Vydání: 3rd Edition
Vazba: Hardback
Počet stran: 332
Dostupnost: Skladem
Původní cena: 4 266 Kč
Výstavní cena:
3 413 Kč(t.j. po slevě 20%)
(Cena je uvedena včetně 10% DPH)
Katalogová cena: 107 GBP
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Termín dodání na naši pobočku v Brně je přibližně 3-4 týdny.
Drug Stereochemistry: Analytical Methods and Pharmacology, Third Edition covers all aspects of chiral drugs from academic, governmental, industrial, and clinical perspectives, reflecting the many advances in techniques and methodology. Topics include: The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery How stereochemistry impacts decisions made in the absorption, distribution, metabolism, excretion, and toxicity (ADMET) stages of drug discovery Pharmacokinetics and pharmacodynamics and the issues faced during the final stages of the drug development process The impact of the International Conference on Harmonisation (ICH) on the use of single isomer drugs Chiral switches The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs Patent issues surrounding chiral switches and the marketing of single enantiomer switches The book provides a solid background on stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. It is a one-stop reference for pharmaceutical scientists and chemists working with chiral drug molecules.